Anti-p27 KIP 1 (phospho Thr187) Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

50µl

Țintă

p27 KIP 1

Applications

WB, IHC-P

Reactivity

Human, Mouse, Rat

Formulation

Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

IHC-P: 1:50 - 1:100, WB: 1:500 - 1:1,000

Imunogen

Phospho-specific peptide corresponding to residues surrounding Thr187 of human p27/Kip1.

Specificitate

This antibody recognises p27/Kip1, also known as cyclin-dependent kinase inhibitor p27 or cyclin-dependent kinase inhibitor 1B, when phosphorylated at threonine 187. p27/Kip1 is a cyclin-dependent kinase inhibitor (CKI) that belongs to the Cip/Kip protein family. p27/Kip1 inhibits cyclin-dependent kinases (CDKs) and cyclin-CDK complexes; playing a role in the regulation of cell cycle progression at G1. Phosphorylation of p27/Kip1 at threonine 187 by CDK2 leads to the ubiquitination and subsequent degradation of p27/Kip by the 26S proteosome.

Storage

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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