Anti-Neurofilament Heavy Polypeptide Antibody [SPM203]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Neurofilament Heavy Polypeptide

Applications

Flow Cytometry, WB, IHC-P

Reactivity

Human, Mouse, Rat, Chicken, Porcine

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1

Recommended dilutions

Flow Cytometry: 1-2 µg/million cells, WB: 1-2 µg/ml, IHC-P: 0.25-0.5 µg/ml

Molecular weight

200 kDa

Light chain

kappa

Clonă

SPM203

Imunogen

Triton-X 100 insoluble protein fraction of rat brain.

Specificitate

This antibody reacts with a 200kDa protein, identified as heavy sub-unit of neurofilaments (NF-H). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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