Anti-Neisseria Meningitidis Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

1mL

Țintă

Neisseria Meningitidis

Applications

ELISA, IF

Reactivity

Bacterial

Formulation

Supplied in Phosphate Buffered Saline with 0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

5 mg/ml

Isotype

IgG

Imunogen

Whole cell preparation of N. meningitidis types A, B and C.

Specificitate

This antibody recognises Neisseria meningitidis serogroups A, B and C recognizing multiple antigens. Other serogroups have not been tested.N. meningitidis is a gram-negative bacteria that is a causative agent of meningitis. There are 13 known significant serogroups, classified according to the structure of their polysaccharide capsule. Serogroups, A, B, C, D, X, Y, Z, 29E and W135 are responsible for virtually all cases of the human disease.The carbohydrate component of the capsular membrane induces a T cell independent immune response, so neither long term immunity by memory cell formation nor antibody affinity maturation is observed. Rather than being engulfed and processed by an antigen presenting cell, the carbohydrate capsule interacts directly with B cells. This interaction causes production of serogroup specific antibodies, primarily IgM. IgG is also produced with an IgG1 response predominating in children and an IgG2 response predominating in adults.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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