Anti-Myelin PLP Antibody [plpc1]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Myelin PLP

Applications

WB, IHC-P, IF, Flow Cytometry, IHC-Fr

Reactivity

Bovine, Human, Tenerife lizard (Gallotia galloti)

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG2a

Clonă

plpc1

Secvență

GRGTKF

Imunogen

Synthetic peptide sequence GRGTKF corresponding to C terminal region of myelin proteolipid protein.

Specificitate

This antibody recognises myelin proteolipid protein (PLP) in many mammalian species. Clone plpc1 also recognises the alternative PLP splice variant lacking part of the cytoplasmic domain (amino acids 117-151), known as DM20. PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease. Mouse anti myelin proteolipid protein, clone plpc1 has proved a useful immunohistochemical tool for the study of central nervous system injury in patients with multiple sclerosis (Seewan et al. 2011, Huizinga et al. 2011)

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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