Anti-Myelin Basic Protein Antibody [MBP/4275]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Myelin Basic Protein

Applications

ELISA, ICC, WB, IF, IHC-P

Reactivity

Human, Chicken, Guinea Pig, Rat, Porcine, Rabbit, Sheep

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG

Recommended dilutions

ICC: 0.5-1 µg/ml, WB: 1-2 µg/ml, IF: 1-2 µg/ml, IHC: 1-2 µg/ml

Molecular weight

13-21 kDa

Clonă

MBP/4275

Imunogen

Spleen cells from an immunised outbred rat were fused with cells of the mouse NS0 myeloma cell line.

Specificitate

Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. MBP/4275 is used in clinical diagnostics to detect MBP levels or myelination in human MBP. MBP/4275 is used in a two-site ELISA with clone MBP/4273. Both are used interchangeably as capture and detection antibody.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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