Anti-MUM1 Antibody [MUM1/8560R]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

MUM1

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG

Recommended dilutions

IHC: 1-2 µg/ml

Molecular weight

52 kDa

Light chain

kappa

Clonă

MUM1/8560R

Imunogen

Recombinant fragment (corresponding to C-terminal) of IRF4 protein. The exact sequence is proprietary.

Specificitate

MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4). MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed. MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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