Anti-MMP1 Antibody [3B6]

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Descriere

Specificații

Brand

Antibodies

Mărimi disponibile

100µg · 200µg

Țintă

MMP1

Applications

WB, IHC-P

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Molecular weight

Approximately 37 kDa

Clonă

3B6

Imunogen

Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-1.

Specificitate

This antibody recognises human matrix metalloproteinase 1 (MMP-1), also known as interstitial or fibroblast collagenase, a 469 amino acid, in the pro-peptide form, zinc-dependent endopeptidase responsible for degrading the extracellular matrix. MMPs are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. MMP expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma. MMP-1 is overexpressed in invasive melanoma, colorectal and esophageal cancers (Langenskiöld et al. 2013). MMP-1 has also been implicated in arthritis and may influence atherosclerotic lesion formation. Additionally, MMP-1 has been implicated in the repair processes of the heart after myocardial infarction. Mouse anti Human MMP-1 has been used successfully for the detection of MMP-1 in gastric cancer by both Western blotting and immunohistochemistry.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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