Anti-Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody [DT101 + BC199 + T311 + HMB45] - BSA and Azide free

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Melanoma Marker (MART-1 + Tyrosinase + gp100)

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Conjugate

Unconjugated

Host

Mouse

Clonality

Oligoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2b, kappa + IgG1, kappa + IgG2a, kappa

Recommended dilutions

IHC-P: 1-2 µg/ml

Molecular weight

20-22 kDa (doublet) (MART-1): 90-100 kDa (gp100) / 70-80 kDa (Tyrosinase)

Clonă

DT101 + BC199 + T311 + HMB45

Imunogen

Clone DT101 & BC199: Recombinant human MART-1 protein. Clone HMB45: Extract of pigmented melanoma metastases from lymph nodes. Clone T311: Recombinant tyrosinase protein.

Specificitate

This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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