Anti-MCM3 Antibody [MCM3/6706]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

MCM3

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1

Recommended dilutions

IHC: 1-2 µg/ml

Molecular weight

115 kDa

Light chain

kappa

Clonă

MCM3/6706

Imunogen

Recombinant fragment (aa 650-750) of human MCM3 protein. The exact sequence is proprietary.

Specificitate

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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