Anti-MCL1 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

MCL1

Applications

WB

Reactivity

Human

Formulation

Supplied in phosphate-buffered saline with 0.02% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG

Recommended dilutions

WB: 0.5 - 1 µg/ml

Molecular weight

Approximately 30 kDa and 38 kDa in Human Raji cell lysates.

Protein Length

16

Imunogen

A peptide corresponding to 16 amino acids near the centre of human MCL-1.

Specificitate

This antibody recognises an epitope within the central region (IN) of human Myeloid cell leukaemia sequence 1 (MCL-1), an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumours.The MCL-1 protein, localised to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival.recognises both the MCL-1L (~38 kDa) and MCL-1S (~30 kDa) isoforms of MCL-1.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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