Anti-LRP1 Antibody [A2Mr alpha-2]

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Descriere

Specificații

Brand

Antibodies

Mărimi disponibile

100µg · 200µg

Țintă

LRP1

Applications

WB, IP, Flow Cytometry, IHC-Fr, ELISA, IF

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Recommended dilutions

ELISA: Direct, Flow Cytometry: 1:50 1:100, WB: Non-reducing conditions, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Clonă

A2Mr alpha-2

Imunogen

Purified alpha-2 macroglobulin receptor.

Specificitate

This antibody recognises human CD91, also known as Prolow-density lipoprotein receptor-related protein 1, Alpha-2-macroglobulin receptor or apolipoprotein E receptor. CD91 is a 4525 amino acid protein post translationally cleaved into 3 subunits, a 85 kDa type I transmembrane carboxyl chain (LRP85) non-covalently bound to a 515 kDa extracellular N-terminal subunit (LRP515)containing multiple EGF-like and LDL-receptor Class A and Class B domains. Additionally, there is an intracellular domain (LRPICD) which can be cleaved from the transmambrane domain by gamma secretase. Clone A2Mr alpha-2 detects an epitope within the LRP515 chain.CD91 is a multifunctional protein involved in processes inluding the phagocytosis and endocytosis of apoptotic cells , clearance of activated serum alpha-2-macroglobulin , modulation of the inflammatory response and acts as a receptor for Pseudomonas aeruginosa exotoxin A. Mouse anti Human CD91, clone A2Mr alpha-2 has been used extensively for the detection of CD91 by flow cytometry and immunohistochemistry on formalin fixed paraffin embedded tissues.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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