Anti-Lipoprotein Lipase Antibody [5D2] (HRP)

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Lipoprotein Lipase

Applications

WB, ELISA, IP

Reactivity

Bovine, Rat, Human, Chicken, Guinea Pig

Formulation

Supplied in Phosphate Buffered Saline with 0.01% Thiomersal.

Conjugate

HRP

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Molecular weight

Approximately 53 kDa using partially purified LPL from postheparin plasma.

Cross reactivity

This antibody does not cross-react with Mouse.

Clonă

5D2

Imunogen

Purified bovine milk lipoprotein lipase.

Specificitate

This antibody recognises an epitope within amino acids 380-410 of lipoprotein lipase (LPL), a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues.A deficiency of LPL can result in hypertriglyceridemia, and LPL plays a critical role in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. Mouse anti Lipoprotein lipase antibody, clone 5D2 is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Mouse anti Lipoprotein lipase antibody, clone 5D2 inhibits the activity of human LPL.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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