Anti-Integrin beta 3 Antibody [HM beta 3.1] (PE)

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Descriere

Specificații

Brand

Antibodies

Mărime

100T

Țintă

Integrin beta 3

Applications

Flow Cytometry

Reactivity

Mouse, Rat

Formulation

Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.

Conjugate

PE

Host

Hamster

Clonality

Monoclonal

Product form

Lyophilized

Concentration

Reconstitution dependent.

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG

Recommended dilutions

Flow Cytometry: Neat - 1:10, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl. The Fc region of monoclonal antibodies may bind to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (BUF041A/BUF041B).

Reconstitution

Reconstitute with 1 ml of distilled water.

Clonă

HM beta 3.1

Imunogen

Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4.

Specificitate

This antibody recognises the murine integrin beta 3 subunit (CD61), a ~90 kDa a type I membrane protein, expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin.Hamster anti Mouse CD61 antibody, clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin.

Storage

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.

Documentație

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