Anti-Integrin alpha V Antibody [NKI-M7]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Integrin alpha V

Applications

ELISA, Flow Cytometry, IHC-Fr, IP

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG1

Clonă

NKI-M7

Imunogen

Cultured melanoma cells derived from a human melanoma metastasis.

Specificitate

This anitbody detects a melanoma-associated proteoglycan (MW greater than 450-250 kDa) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kDa respectively. It reacts with cultured melanomas melanomas in frozen sections, and blocks fibronectin-induced chemotaxic motility and chemokinesis of melanoma cells. The antigen is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells. In addition to their membrane localization, the antigens are abundant in extracellular adhesion plaques deposited by cultured melanoma cells. NKI-M7 stains primary tumors heterogeneously, whereas metastases are homogeneously stained.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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