Anti-iNOS Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

50µg

Țintă

iNOS

Applications

WB, IP

Reactivity

Mouse, Rat, Bovine

Formulation

Supplied in Phosphate Buffered Saline with 50% Glycerol and <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG

Recommended dilutions

WB: 1:1,000

Molecular weight

Approximately 130 kDa by Western Blot

Protein Length

14

Secvență

KKGSALEEPKATRL

Imunogen

Synthetic peptide corresponding to amino acids 1131-1144 of mouse iNOS.

Aminoacizi

aa 1131 - 1144

Specificitate

This antibody recognises inducible nitric oxide synthase also known as iNOS and NOS type II. This enzyme triggers the synthesis of the second messenger molecule, nitric oxide (NO), by immune cells such as macrophages in response to pathogen exposure. Inducible nitric oxide synthase also becomes activated in response to interleukin 1 beta and tumor necrosis factor alpha. In endothelia, the molecule is produced by eNOS (endothelial nitric oxide synthase) where it acts as a vasodilator and platelet inhibitor while in the brain NO is produced by nNOS (neuronal nitric oxide synthase) and functions as a neurotransmitter.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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