Anti-Indoleamine 2, 3-dioxygenase Antibody [10.1]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Indoleamine 2, 3-dioxygenase

Applications

IHC-Fr, WB

Reactivity

Human, Mouse

Formulation

Supplied in Phosphate Buffered Saline with 0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG3

Molecular weight

45 kDa in IFN-gamma treated human cell lines. This antibody recognizes a slightly lower molecular weight band in Mouse IDO compared to its human counterpart.

Protein Length

107

Clonă

10.1

Secvență

LARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTV

Imunogen

A peptide corresponding to amino acids 78-184 of human IDO fused to GST.

Aminoacizi

aa 78 - 184

Specificitate

This antibody recognises Indoleamine-pyrrole 2,3 - dioxygenase (IDO), an enzyme responsible for the catabolism of tryptophan to N-formylkynurenine and kynurenine. With the exception of tryptophan oxidase in hepatocytes, IDO is the only enzyme that degrades the amino acid tryptophan to kynurenine. Chlamydial pathogens require tryptophan for growth. IDO can lower available tryptophan in target cells leading to conversion of the pathogen to persistant forms, with significance in the progression to chronic infection with its associated pathological effects.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at 4°C.

Documentație

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