Anti-IL-23R Antibody

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

IL-23R

Applications

WB, IHC-P

Reactivity

Human, Mouse

Formulation

Supplied in Phosphate Buffered Saline with 0.1% BSA and 0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Goat

Clonality

Polyclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG

Recommended dilutions

IHC-P 1: 1:125, WB: 1:500

Protein Length

29

Secvență

CQPRKLHFYKNGIKERFQITRINKTTARL

Imunogen

Synthetic peptide sequence CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminus of human IL-23 receptor.

Aminoacizi

aa 59 - 87

Specificitate

This antibody recognises the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kDa single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two fibronectin type III domains. Multiple potential isoforms formed by alternative splicing are described. recognises an epitope within the N-terminal region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4 (UniProt: Q5VWK5), the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signaling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 and susceptibility to the ulcerative and inflammatory psoriasis (Hüffmeier et al. 2009).Goat anti Human Interleukin-23 receptor antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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