Anti-IL-18BP Antibody - BSA and Azide free

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

IL-18BP

Applications

WB, ELISA 

Reactivity

Mouse

Formulation

Supplied in Phosphate Buffered Saline.

Conjugate

Unconjugated

Host

Goat

Clonality

Polyclonal

Product form

Lyophilized

Concentration

1 mg/ml after reconstitution.

Isotype

IgG

Recommended dilutions

ELISA: 0.5 µg/ml - 2.0 µg/ml, WB: 0.1 µg/ml - 0.2 µg/ml

Reconstitution

Reconstitute with 0.1 ml of distilled water.

Endotoxin level

< 0.1 ng/µg of protein (< 1 EU/µg)

Imunogen

E. coli derived recombinant mouse interleukin-18BP.

Specificitate

This antibody recognises interleukin-18-binidng protein (IL-18BP), also known as tadekinig-alpha. IL-18BP is a secreted immunoregulatory binding protein which binds to and inhibits the cytokine activity of mature IL-18 with high affinity. IL-18 plays a role in host defense, inflammation, tissue repair, and regeneration (Mühl & Bachmann 2019). IL-18BP is constitutively expressed in the spleen, PBMCs, monocytes and umbilical vein endothelial cells (Mühl & Bachmann 2019, Corbaz et al. 2002). It is detectable in the serum of healthy humans at a 20 fold molar excess compared to IL-18, with subjects showing levels of 2,000 – 4,000 pg/ml of IL-18BP. IL-18BP is upregulated in response to inflammation as part of the inflammation resolution process. Additionally, it can be upregulated during various cancers and IL-18BP levels are also affected by viral infections such as dengue and hepatitis C (Mühl & Bachmann 2019).

Storage

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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