Anti-IGF2BP2 / IMP-2 Antibody [PCRP-IGF2BP2-1F9]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

IGF2BP2/IMP-2

Applications

Flow Cytometry

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG

Recommended dilutions

Flow Cytometry: 1-2 µg/million cells

Molecular weight

105 kDa

Clonă

PCRP-IGF2BP2-1F9

Imunogen

Recombinant full-length human IGF2BP2 protein.

Specificitate

IGF2BP2 (Insulin-like growth factor 2 mRNA binding protein 2) is also known as IGF2 mRNA-binding protein 2, IMP-2 (IGF-II mRNA-binding protein 2), VICKZ family member 2 or hepatocellular carcinoma autoantigen p62 and is a 556 amino acid protein. IGF2BP2 is expressed in a variety of tissues including heart, placenta, skeletal muscle, pancreas, fetal liver, lung, kidney, thymus and gonadal cells. IGF2BP2 is an RNA binding protein which may be involved in the regulation of mRNA translation and may also function to control the spatial localization of target mRNAs. Antibodies against IGF2BP2 have been detected in patients with HCC (hepatocellular carcinoma), suggesting that IGF2BP2 may have a role in the pathogenesis of HCC. Defects in IGF2BP2 are thought to be associated with susceptibility to type two diabetes mellitus.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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