Anti-GSK3 beta (phospho Ser9) Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

GSK3 beta

Applications

WB

Reactivity

Rat, Mouse, Dog, Primate, Xenopus, Human, Bovine, Chicken, Zebrafish

Formulation

Supplied in 10mM Hepes, pH 7.5, with 50% Glycerol, 0.01% BSA, and 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

WB: 1:1,000

Molecular weight

Approximately 46 kDa in rat cortex cell lysates.

Imunogen

Phosphopeptide corresponding to amino acid sequence surrounding phoshorylated Ser9 of rat GSK3 beta.

Specificitate

This antibody recognises GSK3 beta, also known as glycogen synthase kinase-3 beta (GSK-3 beta), factor A (FA) and serine/threonine-protein kinase GSK3B, when phosphorylated at serine 9. GSK3 is a ~46 kDa member of the serine/threonine protein kinase family. Two isforms of GSK3 exist, alpha and beta. GSK3 beta is expressed in the testis, thymus, prostate, and ovary as well as being expressed at low levels in lung, brain and kidney tissue.GSK3 beta is involved in many signalling pathways including energy metabolism, body pattern formation and microtubule growth and stability (which aids axon growth). GSK3 beta is also thought to be involved in oncogenesis and the hormonal control of several regulatory proteins including glycogen synthase.Phosphorylation of serine-9 inhibits GSK3 beta function.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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