Anti-Growth Hormone Antibody [GhB9]

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Descriere

Specificații

Brand

Antibodies

Mărime

200µg

Țintă

Growth Hormone

Applications

ELISA

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Clonă

GhB9

Imunogen

Purified recombinant human growth hormone.

Specificitate

This antibody recognises human growth hormone (hGH), a 22 kDa polypeptide synthesised by acidophilic or somatotropic cells of the anterior pituitary gland. It is also referred to as somatotropin. Many different isoforms exist in humans, from monomers to pentamers, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Human GH binds to two GH receptors and induces signal transduction through receptor dimerisation. Growth hormone plays an important role in growth and cell production. An excess of GH results in acromegaly or gigantism, characterised by excessive growth. It can also be accompanied by muscle weakness, insulin resistance and pressure on nerves. Deficiency of GH may result in lack of strength, energy and bone mass. Growth hormone can be used to treat conditions that result in short stature or decreased muscle mass.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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