Anti-GATA3 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

50µg

Țintă

GATA3

Applications

WB, IHC-P, IF, ICC

Reactivity

Human

Formulation

Supplied in Phosphate Buffered Saline with 1 mg/ml BSA, 30% Glycerol, and <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

1 mg/ml

Isotype

IgG

Recommended dilutions

ICC: 1:50 - 1:500

Molecular weight

Approximately 55 kDa in SH-SY5Y cell lysate and SH-SY5Y nuclear extract.

Imunogen

Purified partial recombinant GATA3 protein expressed in E. coli.

Specificitate

This antibody recognises GATA3, also known as Trans-acting T-cell-specific transcription factor GATA-3 or GATA-binding factor 3. The protein is a member of the GATA family of transcription factors, which has received its name from binding DNA sequences containing the GATA consensus motif 5'-[AT]GATA[AG]-3' (uniprot P15976).GATA3 has been shown to play a critical role in T cell development and the differentiation of T helper 2 (Th2) cells. In addition, GATA3 has been implied to have tissue specific functions such as a regulatory role in the development of the mammary gland epithelium and skin tissue. Aberrant GATA3 levels have been identified in a variety of cancers including breast cancer. Indeed, GATA3 has become a marker for certain breast cancer types and GATA3 antibodies are commonly used for the immunohistochemical evaluation of breast cancer samples.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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