Anti-GAPDH Antibody [6C5] - Identical to Abcam (ab8245)

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

200µg

Țintă

GAPDH

Applications

WB, ELISA, IF, IHC-Fr, IP

Reactivity

Rabbit, Human, Pig, Dog, Cat, Rat, Mouse, Xenopus, Tube-nosed Bat, Chicken, Vertebrates, Sheep, African green monkey , Crucian Carp

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A affinity chromatography of tissue culture supernatant.

Isotype

IgG1

Clonă

6C5

Imunogen

Rabbit muscle GAPDH.

Specificitate

This antibody recognises glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a ~36 kDa multifunctional protein whose main function is to catalyse the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate, in conjunction with inorganic phosphate and nicotinamide adenine dinucleotide (NAD). This reaction is an important energy yielding step in carbohydrate metabolism. GAPDH has also been shown to translocate to the nucleus under a variety of stressors, most of which are associated with oxidative stress, whereby it mediates cell death. A further report has shown that GAPDH binds to several proteins that are responsible for neurodegenerative diseases, such as amyloid precursor protein and Huntingtin.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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