Anti-Endothelin B Receptor / ET-B Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Endothelin B Receptor/ET-B

Applications

IHC-P, IF, IP, ICC

Reactivity

Rat, Mouse, Human

Formulation

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Sheep

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

IF: 10 - 20 µg/ml, IHC-P: 10 - 20 µg/ml, IP: 20 - 40 µg/ml

Protein Length

14

Secvență

KANDHGYDNFRSSNN

Imunogen

Synthetic peptide sequence KANDHGYDNFRSSNN corresponding to amino acids 424-437 of the C-terminus of rat endothelin B receptor, conjugated to Keyhole Limpet Haemocyanin.

Aminoacizi

aa 424 - 437

Specificitate

This antibody recognises an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. recognises epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. AAR43 does not block the binding of endothelins. Sheep anti Rat endothelin B receptor antibody (AAR43) is suitable for use in immunocytochemistry on acetone fixed cells.

Storage

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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