Anti-EGFR Antibody [GFR450] (CF® 488)

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100T

Țintă

EGFR

Applications

Flow Cytometry, IF

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

CF®488

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

100 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2a

Recommended dilutions

Flow Cytometry: 5 µl / million cells or 5 µl / 100 µl whole blood, IF: 1:50-1:100

Molecular weight

~170 kDa (wild type) / ~145 kDa (vIII variant)

Cross reactivity

This antibody does not cross-react with Mouse.

Light chain

kappa

Clonă

GFR450

Imunogen

Recombinant extracellular domain of human EGFR protein.

Specificitate

This antibody recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Storage

Store at 4-8°C. Antibody is stable for 24 months.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului