Anti-Dynorphin A Antibody

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µl

Țintă

Dynorphin A

Applications

IHC-P, IHC-Fr, RIA

Reactivity

Porcine, Rat, Rhesus Monkey, Human

Formulation

Supplied as diluted serum in Phosphate Buffered Saline with 0.1% BSA and 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

IHC-Fr: 1:100 - 1:1500, RadioIAs: 1:10,000

Purity

Diluted Serum.

Protein Length

17

Secvență

YGGFLRRIRPKLKWDNQ

Imunogen

Porcine Dynorphin A, amino acids 1-17: YGGFLRRIRPKLKWDNQ.

Aminoacizi

aa 1 - 17

Specificitate

This antibody recognises the opioid peptide dynorphin A , a cleavage product of big dynorphin, itself derived from the precursor pro-encephalin-B, also known as preprodynorphin. Rabbit anti dynorphin A antibody binds to both dynorphin A 1-17 and 1-8 but not with other big dynorphin cleavage products such as dynorphin B, also known as rimorphin. Dynorphin A immunoreactive cells are found in the paraventricular and supraoptic nucleus and in hippocampal mossy fibers of rat brain following kainic acid administration and colchicine induced neurotoxicity. Dynorphins play a role in multiple physiologic processes including pain perception and responses to stress (Rácz et al. 2013). They mimic and compete with a number of opiate drugs(Chavkin 2013). Dysregulation of dynorphin A expression has been linked to progression of neurodegenerative conditions such as Altzheimer’s disease and appears to play a significant role in the pathobiology of epilepsy. Rabbit anti dynorphin antibody has been used successfully for the immunohistochemical demonstration of ‘mossy fibre’ sprouting in hippocampal sclerosis and in a virally induced disease model in the rat.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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