Anti-Cyclin D1 Antibody [SPM587] (PE)

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Descriere

Specificații

Brand

Antibodies

Mărime

100T

Țintă

Cyclin D1

Applications

Flow Cytometry, IF

Reactivity

Human, Monkey, Mouse, Rat

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

PE

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

100 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2a

Recommended dilutions

Flow Cytometry: 5-10 µl / million cells, IF: 1:50-1:100

Molecular weight

36 kDa

Light chain

kappa

Clonă

SPM587

Imunogen

Recombinant full-length human Cyclin D1 protein.

Specificitate

This antibody recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Storage

Store at 4-8°C. Antibody is stable for 24 months.

Documentație

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