Anti-Clusterin Antibody [CLU/4727]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Clusterin

Applications

WB, IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2c

Recommended dilutions

WB: 2-4 µg/ml, IHC-P: 1-2 µg/ml

Molecular weight

70 kDa (precursor) / 36-39 kDa (alpha) / 34-36 kDa (beta)

Light chain

kappa

Clonă

CLU/4727

Imunogen

Recombinant fragment, around amino acids 185-287, of human Clusterin protein. The exact sequence is proprietary.

Specificitate

Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, α and β, are associated through disulfide bonds. The β subunit (also called ApoJα) corresponds to residues 23-227. The α subunit (also called ApoJβ) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences β-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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