Anti-Cholera Toxin beta Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

1mL

Țintă

Cholera Toxin beta

Applications

ELISA, Immunodiffusion

Reactivity

Bacterial

Formulation

Supplied in Phosphate Buffered Saline with 0.1% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

5 mg/ml

Isotype

IgG

Imunogen

Purified choleragenoid.

Specificitate

This antibody recognises the beta subunit of cholera toxin.The beta subunit of cholera toxin binds to a GM1-ganglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit (and cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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