Anti-CEACAM1 + CEACAM3 + CEACAM6 Antibody [YTH71.3]

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Descriere

Specificații

Brand

Antibodies

Mărime

200µg

Țintă

CEACAM1 + CEACAM3 + CEACAM6

Applications

IHC-P, Flow Cytometry, IHC-Fr

Reactivity

Human, Rhesus Monkey

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Rat

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG2a

Recommended dilutions

IHC-P: 10 µg/ml, Use 10µl of the suggested working dilution to label 1 x 10⁶ cells in 100µl.

Cross reactivity

This antibody does not cross-react with Mouse.

Clonă

YTH71.3

Imunogen

Human lymphocytes.

Specificitate

This antibody recognises 3 members of the human CD66 family, namely CD66a, also known as Carcinoembryonic antigen-related cell adhesion molecule 1, Biliary glycoprotein 1 or CEACAM1. Clone YTH71.3 also recognises CD66c, known as Carcinoembryonic antigen-related cell adhesion molecule 6 or Non-specific crossreacting antigen. In addition the clone also recognises CD66d which in turn is also known as Carcinoembryonic antigen-related cell adhesion molecule 3 or CGM1. CD66 family members are single pass, type 1 membrane glycoproteins bearing a single V-type Ig-like domain and a varying number of C2-type Ig-like domains. Clone YTH71.3 recognises epitopes in the N-terminal domain of these CD66 family members.CD66 members are expressed by human neutrophils and cells of the colon where it is down regulated in some cases of colon carcinoma. CD66a is also expressed in the human alveolar adenocarcinoma cell line A549 and may play a role in Moraxella catarrhalis induced apoptosis of pulmonary epithlial cells in diseases including COPD and emphysema (N'Guessan et al. 2007).

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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