Anti-CD40 Antibody [FGK45.5]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

CD40

Applications

Functional Studies, Flow Cytometry, IF

Reactivity

Mouse

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Rat

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2a

Recommended dilutions

Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml

Molecular weight

48 kDa

Cross reactivity

This antibody does not cross-react with Human.

Light chain

kappa

Clonă

FGK45.5

Imunogen

Recombinant mouse CD40 fusion protein.

Specificitate

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului