Anti-CD30 Antibody [rKi-1/6913] - BSA and Azide free

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

CD30

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein A chromatography.

Isotype

IgG1

Recommended dilutions

IHC-P: 1-2 µg/ml

Molecular weight

105 - 120 kDa

Light chain

kappa

Epitope

The epitope for this antibody is within the cytoplasmic region, specifically amino acids 495-595.

Clonă

rKi-1/6913

Imunogen

Recombinant fragment corresponding to human CD30 protein.

Specificitate

This antibody recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. Its epitope is located somewhere between aa 580-595 (cytoplasmic). CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin s disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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