Anti-CD3 epsilon Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

CD3 epsilon

Applications

WB

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A chromatography.

Isotype

IgG

Recommended dilutions

WB: 1-2 µg/ml.

Molecular weight

20 kDa

Cross reactivity

This antibody is predicted to cross react with Ape, Orangutan, Gibbon, Chimpanzee, Monkey, Elephant, Horse, Bovine, Sheep, Porcine, Canine, Feline, Rabbit, Rat, Mouse, Guinea Pig, Hamster, Opossum, Frog, and Chicken.

Secvență

ERPPPVPNPDYEP

Imunogen

Synthetic peptide corresponding to amino acids 156-168 of human CD3e.

Specificitate

This antibody recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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