Anti-CCL23 Antibody [CCL23/4034]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

CCL23

Applications

IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG2

Recommended dilutions

IHC: 1-2 µg/ml

Molecular weight

13 kDa

Light chain

kappa

Clonă

CCL23/4034

Imunogen

Recombinant fragment (around Amino Acids 1-120) of human CCL23 protein. The exact sequence is proprietary.

Specificitate

Small inducible cytokine A23 precursor (CCL23), or CK-b-8, is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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