Anti-CCK4 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

CCK4

Applications

WB, IHC-P

Reactivity

Human, Rat, (Mouse)

Formulation

Supplied in phosphate-buffered saline with 0.02% Sodium Azide.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Affinity-chromatography

Isotype

IgG

Recommended dilutions

WB: 0.5 - 1 µg/ml

Molecular weight

Approximately 86 kDa in colon tissue lysates.

Protein Length

15

Imunogen

A peptide corresponding to 15 amino acids near the N-terminus of human PTK7.

Specificitate

This antibody recognises the N-terminal region of human Protein tyrosine kinase-like 7 (PTK7), a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle.PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates.PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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