Anti-Carbonic Anhydrase 2 / CA2 Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

1mL

Țintă

Carbonic Anhydrase 2/CA2

Applications

WB, IF, Immunodiffusion

Reactivity

Human

Formulation

Supplied in Glycine Buffered Saline with <0.1% Sodium Azide, 0.1% EACA, 0.01% Benzamidine, and 1 mM EDTA.

Conjugate

Unconjugated

Host

Sheep

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

WB: 1:1,000

Molecular weight

Approximately 18 kDa in rat adrenomedullary chromaffin cell lysates.

Imunogen

Purified human carbonic anhydrase II (CAII) prepared from erythrocytes.

Specificitate

This antibody recognises human carbonic anhydrase II, also known as Carbonate dehydratase II or Carbonic anhydrase C. Carbonic anhydrase II is a 259 amino acid ~30 kDa enzyme essential for bone resorption and osteoclast differrentiation.Mutations in the CA2 gene has been identified as the cause of osteopetrosis, autosomal recessive 3 (OPTB3), a rare disease characterized by particularly dense bone, cerebral calcification and renal tubular acidosis (Shah et al 2004).Product identity is confirmed by double diffusion vs human CAII. No reactivity is seen in immunodiffusion against CAI.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

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