Imagine indisponibilăAnti-C4d Antibody [C4D204] (CF® 488)
Pe scurt
Anti-C4d Antibody [C4D204] (CF® 488) este un anticorp monoclonal de șoarece împotriva țintei C4d, cu reactivitate declarată pentru Human. Este validat pentru ELISA, IF, IHC-P, are izotipul IgG1 și este conjugat cu CF®488. Se livrează în mărimea 100T, la prețul de 3.826,63 lei cu TVA.
Produse destinate exclusiv cercetării. Nu se utilizează în diagnostic sau tratament.
Descriere
Mouse monoclonal [C4D204] antibody to C4d (CF® 488).
Specificații
- Brand
- Antibodies
- Mărime
- 100T
- Țintă
- C4d
- Applications
- ELISA, IF, IHC-P
- Reactivity
- Human
- Conjugate
- CF®488
- Host
- Mouse
- Clonality
- Monoclonal
- Product form
- Liquid
- Concentration
- 100 µg/ml
- Purification
- Protein A/G chromatography.
- Isotype
- IgG1
- Recommended dilutions
- ELISA: 1-2 µg/ml, IF: 1:50-1:100, IHC-P: 1:200-1:400
- Molecular weight
- 192 kDa (predicted)
- Light chain
- kappa
- Clonă
- C4D204
- Imunogen
- Recombinant human Complement 4d protein.
- Specificitate
- This antibody is specific to Complement 4d (C4d) and reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.
Documentație
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