Anti-Bax Antibody [2D2]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Bax

Applications

Flow Cytometry, IF, WB, IHC-P

Reactivity

Human, Monkey

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1

Recommended dilutions

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Molecular weight

21 kDa

Cross reactivity

This antibody does not cross-react with Mouse or Rat.

Light chain

kappa

Clonă

2D2

Secvență

Cys-GSGEQPRGGGPTSS

Imunogen

Synthetic peptide corresponding to amino acids 3-16 of human Bax protein.

Specificitate

This antibody recognizes a protein of 21kDa, identified as the Bax protein. This MAb is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein. Bcl-2 blocks cell death following a variety of stimuli. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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