Anti-AMPK alpha 1 + AMPK alpha 2 Antibody [34.2]

Pe scurt

Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

AMPK alpha 1 + AMPK alpha 2

Applications

WB, IHC-Fr, ELISA, IF, IP

Reactivity

Drosophila, Vertebrates, Human, Mouse, Rat

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

1 mg/ml

Purification

Protein G affinity chromatography of tissue culture supernatant.

Isotype

IgG2a

Recommended dilutions

WB: 1:100-1:1,000

Molecular weight

Approximately 63 kDa in rat brain cell lysates.

Protein Length

29

Clonă

34.2

Imunogen

A peptide corresponding to 29 amino acids within the N-terminal catalytic domain of Drosophila AMPK alpha.

Specificitate

This antibody recognises both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilized by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels.AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.

Storage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Documentație

• Fișă tehnică (PDF)se deschide pe site-ul producătorului