Anti-Aldose reductase Antibody [rAKR1B1/7296]

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Descriere

Specificații

Brand

Antibodies

Mărime

100µg

Țintă

Aldose reductase

Applications

IF, WB, IHC-P

Reactivity

Human

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conjugate

Unconjugated

Host

Mouse

Clonality

Monoclonal

Product form

Liquid

Concentration

200 µg/ml

Purification

Protein A/G chromatography.

Isotype

IgG1

Recommended dilutions

IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Molecular weight

37 kDa

Light chain

kappa

Clonă

rAKR1B1/7296

Imunogen

Recombinant human full-length AKR1B1 protein.

Specificitate

AKR1B1, also designated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Documentație

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