Anti-Acid Sphingomyelinase Antibody

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Descriere

Specificații

Brand

Antibodies

Mărime

50µl

Țintă

Acid Sphingomyelinase

Applications

WB

Reactivity

Human, Rat, (Mouse)

Formulation

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Conjugate

Unconjugated

Host

Rabbit

Clonality

Polyclonal

Product form

Liquid

Concentration

Lot Specific

Isotype

IgG

Recommended dilutions

WB: 1:500-1:2,000

Imunogen

Recombinant protein of human SMPD1 / ASM.

Specificitate

This antibody recognises sphingomyelin phosphodiesterase, also known as ASM, Sphingomyelin Phosphodiesterase, ASMASE and NPD. It is a lipid hydrolase that converts sphingomyelin to the bioactive messenger ceramide, and is activated by a number of molecules including TNF-alpha and LPS. Mutations in the SMPD1 gene resulting in deficient ASM production cause Niemann-Pick disease, one type of which causes lethality within three years of life (Schuchman 2007). SMPD1 mutations have also been implicated in sporadic Parkinson's disease. A role of ASM on mood regulation has been suggested, with high ASM expression implicated in major depressive episodes.

Storage

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Documentație

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